Pipeline for Investigating Underlying Mechanisms of Alzheimer’s Disease
2019 CSF Hydrodynamics Symposium
OSLO, NORWAY - JULY 1-2, 2019
John Vardakis, PhD
and his team developed new methodology for studying the underlying mechanisms of Alzheimer's disease. As we learn more about Alzheimer's disease, we find that one possible cause may be neurovascular problems. Neurovascular conditions are often complicated by increased risk factors for cardiovascular disease. Often, several of these neurovascular manifestations can be seen at even the earlier stages of Alzheimer's progression.
Dr. Vardakis and his team analyzed the effects of physical activity (known to combat cardiovascular risks) and several mechanisms in the brain that could make neurovascular disease worsen: clearance of cerebrospinal fluid, blood perfusion and swelling/drainage of CSF.
Using 3D modeling and complex statistical methods, they were able to show associations between physical activity and things that impact Alzheimer's development, including cognitive status, gender, and more. Excitingly, the team also identified areas in different regions of the brain that may be more likely to be implicated in neurodegenderative development.
This presentation was made possible thanks to a generous grant from The Monkton Institute and was presented at the 2019 CSF Hydrodynamics Symposium held in Oslo, Norway.